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TUMOR SUPPRESSOR PROTEIN P53
Descriptors Found:
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DeCS
Descriptor
English
:
Tumor Suppressor Protein p53
Descriptor
Spanish
:
Proteína p53 Supresora de Tumor
Descriptor
Portuguese
:
Proteína Supressora de Tumor p53
Synonyms
English
:
p53 Tumor Suppressor Protein
Tree Number:
D12.776.260.820
D12.776.624.776.775
D12.776.660.825
D12.776.744.845
Definition
English
:
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to
control
CELL PROLIFERATION
and
APOPTOSIS
. A mutant or absent p53 protein has been found in
LEUKEMIA
;
OSTEOSARCOMA
; LUNG CANCER; and
COLORECTAL CANCER.
History Note
English
:
2005(1991);
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29089
Unique Identifier:
D016159
Occurrence in VHL
:
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DeCS
CID-10
SciELO
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